http://www.wowwiki.com/Defense
А именно: Critical Hit immunity for a level 80 player in a Heroic Dungeon is 535 Defense, because mobs in a level 80 heroic 5-man are never higher than level 82.
Critical Hit immunity for a level 80 player against a Raid Boss occurs at 540 Defense. This requires a defense skill of 140, achieved from a combined 689+ Defense Rating from gear, enchants, gems, etc.
Critical Hit immunity for a level 80 player against a Raid Boss can also be achieved by raising Resilience to 5.6%, being a resilience rating of 460.
If the combined critical hit reduction from Defense and Resilience together total 5.6% that will also make the player immune to critical hits from Raid Bosses.